An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma
Joint Authors
Konopleva, Marina
Kadia, Tapan
Boddu, Prajwal
Tang, Guilin
Kanagal-Shamanna, Rashmi
Thakral, Beenu
Jain, Nitin
Jabbour, Elias
Yin, C. Cameron
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
While rare, cases of isolated extramedullary disease of B-cell Lymphoblastic Lymphoma (B-LBL) without morphologic bone marrow involvement have been described.
In this report, we illustrate the case of an elderly gentleman who presented with isolated testicular and vertebral LBL involvement but had no morphologic bone marrow involvement.
The initial plan of treatment was to treat along the lines of Philadelphia negative B-ALL/LBL.
During this time, fluorescence in situ hybridization (FISH) and PCR testing for BCR-ABL1 rearrangements were being performed on the marrow specimens as a part of routine diagnostic workup.
While the FISH returned negative, PCR testing unexpectedly detected BCR-ABL1 fusion transcripts at a low level of 0.48%.
Given their presence, we performed FISH for BCR/ABL1 rearrangement in both testicular and L5 vertebral specimens which were 80–90% positive.
He subsequently received rituximab, hyper-CVAD, and dasatinib, along with prophylactic intrathecal prophylactic chemotherapy.
The patient achieved a prolonged remission but eventually relapsed, 4 years later.
Had it not been for this fortuitous discovery, the patient would not have been treated with tyrosine kinase inhibitors.
We emphasize that FISH and PCR testing for BCR-ABL1 rearrangement are integral to arriving at an accurate diagnosis and should be routinely tested on B-LBL biopsy specimens.
American Psychological Association (APA)
Boddu, Prajwal& Yin, C. Cameron& Kanagal-Shamanna, Rashmi& Tang, Guilin& Thakral, Beenu& Kadia, Tapan…[et al.]. 2017. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1145782
Modern Language Association (MLA)
Boddu, Prajwal…[et al.]. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Reports in Hematology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1145782
American Medical Association (AMA)
Boddu, Prajwal& Yin, C. Cameron& Kanagal-Shamanna, Rashmi& Tang, Guilin& Thakral, Beenu& Kadia, Tapan…[et al.]. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1145782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145782