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Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review
المؤلفون المشاركون
Potts, D. Alan
Cassaday, Ryan D.
Gopal, Ajay
Fromm, Jonathan R.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of hematologic malignancies typically treated with multiagent chemotherapy.
Rarely, spontaneous remissions can be observed, particularly in more indolent subtypes.
The prognosis of aggressive NHL can be predicted using clinical and histopathologic factors.
In aggressive B-cell NHL, the importance of MYC and BCL2 proto-oncogene coexpression (as assessed by immunohistochemistry) and high-grade histologic features are particularly noteworthy.
We report a unique case of spontaneous remission in a patient with an aggressive B-cell NHL which harbored high-risk histopathologic features, including MYC protein expression at 70–80%, BCL2 protein expression, and morphologic features suggestive of high-grade B-cell lymphoma, NOS (formerly B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma [BCLU]).
After undergoing a biopsy to confirm this diagnosis, he opted to forego curative-intent chemotherapy.
The single, yet relatively large area of involvement noted on 18F-fluorodeoxyglucose positron emission tomography-computed tomography steadily resolved on subsequent follow-up studies.
He remained without evidence of recurrence one year later, having never received treatment.
This case emphasizes the potential for spontaneous remission in NHL and demonstrates that this phenomenon can be observed despite contemporary high-risk histopathologic features.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Potts, D. Alan& Fromm, Jonathan R.& Gopal, Ajay& Cassaday, Ryan D.. 2017. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Potts, D. Alan…[et al.]. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review. Case Reports in Hematology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1145790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Potts, D. Alan& Fromm, Jonathan R.& Gopal, Ajay& Cassaday, Ryan D.. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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