Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review
Joint Authors
Potts, D. Alan
Cassaday, Ryan D.
Gopal, Ajay
Fromm, Jonathan R.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of hematologic malignancies typically treated with multiagent chemotherapy.
Rarely, spontaneous remissions can be observed, particularly in more indolent subtypes.
The prognosis of aggressive NHL can be predicted using clinical and histopathologic factors.
In aggressive B-cell NHL, the importance of MYC and BCL2 proto-oncogene coexpression (as assessed by immunohistochemistry) and high-grade histologic features are particularly noteworthy.
We report a unique case of spontaneous remission in a patient with an aggressive B-cell NHL which harbored high-risk histopathologic features, including MYC protein expression at 70–80%, BCL2 protein expression, and morphologic features suggestive of high-grade B-cell lymphoma, NOS (formerly B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma [BCLU]).
After undergoing a biopsy to confirm this diagnosis, he opted to forego curative-intent chemotherapy.
The single, yet relatively large area of involvement noted on 18F-fluorodeoxyglucose positron emission tomography-computed tomography steadily resolved on subsequent follow-up studies.
He remained without evidence of recurrence one year later, having never received treatment.
This case emphasizes the potential for spontaneous remission in NHL and demonstrates that this phenomenon can be observed despite contemporary high-risk histopathologic features.
American Psychological Association (APA)
Potts, D. Alan& Fromm, Jonathan R.& Gopal, Ajay& Cassaday, Ryan D.. 2017. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145790
Modern Language Association (MLA)
Potts, D. Alan…[et al.]. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review. Case Reports in Hematology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1145790
American Medical Association (AMA)
Potts, D. Alan& Fromm, Jonathan R.& Gopal, Ajay& Cassaday, Ryan D.. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145790