LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease

الملخص EN

Background.

To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD).

Methods.

Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected.

Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed.

Risk factors for patients with CAD were analyzed by multiple factor analysis.

Results.

Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients.

Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD.

Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD.

Conclusions.

Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.