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LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
Joint Authors
Tan, Jin
Liu, Shengzhong
Jiang, Qin
Yu, Tao
Huang, Keli
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD).
Methods.
Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected.
Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed.
Risk factors for patients with CAD were analyzed by multiple factor analysis.
Results.
Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients.
Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD.
Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD.
Conclusions.
Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.
American Psychological Association (APA)
Tan, Jin& Liu, Shengzhong& Jiang, Qin& Yu, Tao& Huang, Keli. 2019. LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1146029
Modern Language Association (MLA)
Tan, Jin…[et al.]. LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease. Cardiology Research and Practice No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1146029
American Medical Association (AMA)
Tan, Jin& Liu, Shengzhong& Jiang, Qin& Yu, Tao& Huang, Keli. LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1146029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146029