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A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis
المؤلفون المشاركون
Mochizuki, Hitoshi
Nakazato, Masamitsu
Shiomi, Kazutaka
Sakai, Katsuya
Mochida, Kosuke
Amano, Masahiro
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-22
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
We report an 81-year-old man with multiple liver metastases after tumorectomy for primary mediastinal malignant melanoma, who experienced limb weakness and sensory disturbance after nivolumab monotherapy.
He was diagnosed with nivolumab-induced mononeuropathy multiplex and rhabdomyolysis based on serologic examination, muscle biopsy, magnetic resonance imaging of the limbs, and a nerve conduction study.
A course of intravenous methylprednisolone (mPSL) was initiated at 1 g/day for 3 days.
After that, oral prednisolone (PSL) was started at 1 mg/kg/day and gradually tapered.
Limb muscle strength improved, but when PSL was reduced to 0.3 mg/kg/day, the weakness recurred, and a nerve conduction study showed exacerbation of mononeuropathy multiplex.
The patient was again administered intravenous mPSL (0.5 g/day for 3 days) followed by oral PSL at 0.5 mg/kg/day, and his neurological symptoms improved.
Nivolumab, an immune checkpoint inhibitor, is used for the treatment of advanced melanoma and other cancers and causes various immune-related adverse events (irAEs).
However, neurological irAEs related to nivolumab are rare.
Furthermore, there are no reports of simultaneous nerve and muscle impairment.
Unexpected irAEs affecting various organs should be recognized and treated appropriately.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sakai, Katsuya& Mochizuki, Hitoshi& Mochida, Kosuke& Shiomi, Kazutaka& Amano, Masahiro& Nakazato, Masamitsu. 2017. A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146547
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sakai, Katsuya…[et al.]. A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis. Case Reports in Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146547
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sakai, Katsuya& Mochizuki, Hitoshi& Mochida, Kosuke& Shiomi, Kazutaka& Amano, Masahiro& Nakazato, Masamitsu. A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146547
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146547
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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