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A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis
Joint Authors
Mochizuki, Hitoshi
Nakazato, Masamitsu
Shiomi, Kazutaka
Sakai, Katsuya
Mochida, Kosuke
Amano, Masahiro
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We report an 81-year-old man with multiple liver metastases after tumorectomy for primary mediastinal malignant melanoma, who experienced limb weakness and sensory disturbance after nivolumab monotherapy.
He was diagnosed with nivolumab-induced mononeuropathy multiplex and rhabdomyolysis based on serologic examination, muscle biopsy, magnetic resonance imaging of the limbs, and a nerve conduction study.
A course of intravenous methylprednisolone (mPSL) was initiated at 1 g/day for 3 days.
After that, oral prednisolone (PSL) was started at 1 mg/kg/day and gradually tapered.
Limb muscle strength improved, but when PSL was reduced to 0.3 mg/kg/day, the weakness recurred, and a nerve conduction study showed exacerbation of mononeuropathy multiplex.
The patient was again administered intravenous mPSL (0.5 g/day for 3 days) followed by oral PSL at 0.5 mg/kg/day, and his neurological symptoms improved.
Nivolumab, an immune checkpoint inhibitor, is used for the treatment of advanced melanoma and other cancers and causes various immune-related adverse events (irAEs).
However, neurological irAEs related to nivolumab are rare.
Furthermore, there are no reports of simultaneous nerve and muscle impairment.
Unexpected irAEs affecting various organs should be recognized and treated appropriately.
American Psychological Association (APA)
Sakai, Katsuya& Mochizuki, Hitoshi& Mochida, Kosuke& Shiomi, Kazutaka& Amano, Masahiro& Nakazato, Masamitsu. 2017. A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146547
Modern Language Association (MLA)
Sakai, Katsuya…[et al.]. A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis. Case Reports in Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146547
American Medical Association (AMA)
Sakai, Katsuya& Mochizuki, Hitoshi& Mochida, Kosuke& Shiomi, Kazutaka& Amano, Masahiro& Nakazato, Masamitsu. A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146547