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Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis
المؤلفون المشاركون
Wu, Jiali
He, Lagu
Bai, Le
Tan, Li
Hu, Min
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
IgA vasculitis (lgAV) is the most frequent vessel vasculitis in children, and the prognosis is related to the children’s age and degree of nephritis.
This study is aimed at investigating serum apolipoprotein M (apoM) levels in patients with lgAV patients and at evaluating the association between apoM and disease severity.
Methods.
A total of 109 lgAV patients and 76 age- and sex-matched healthy controls were included.
The age and gender of the study participants were matched.
ApoM levels were measured by an enzyme-linked immunosorbent assay.
Additionally, the serum levels of lipids, apolipoproteins, kidney biochemical profiles, immunoglobulins (IgA, IgG, IgM, and IgE), and the complements (C3 and C4) were assessed using an automatic biochemical analyzer.
Results.
ApoM was increased significantly in lgAV patients compared to healthy controls.
ApoM, meanwhile, was lower in patients with nephritis than in those without nephritis.
The apoM levels were higher in classes I and II IgA vasculitis nephritis (lgAVN) patients than in classes III and IV.
Besides, the apoM serum level<24.81 mg/L was an independent predictive factor for lgAVN and can be independently associated with the presence of nephritis in lgAV patients.
Meanwhile, the serum apoM concentration negatively correlated with the ISKDC grading score in lgAVN patients.
Conclusions.
Serum apoM was elevated in lgAV patients and decreased gradually with the ISKDC grading score.
ApoM (OR=0.32, 95%CI=0.12‐0.85, p=0.023) was identified as a protective factor for nephritis in all lgAV patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jiali& He, Lagu& Bai, Le& Tan, Li& Hu, Min. 2019. Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146917
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jiali…[et al.]. Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146917
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jiali& He, Lagu& Bai, Le& Tan, Li& Hu, Min. Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146917
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146917
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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