Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis
Joint Authors
Wu, Jiali
He, Lagu
Bai, Le
Tan, Li
Hu, Min
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
IgA vasculitis (lgAV) is the most frequent vessel vasculitis in children, and the prognosis is related to the children’s age and degree of nephritis.
This study is aimed at investigating serum apolipoprotein M (apoM) levels in patients with lgAV patients and at evaluating the association between apoM and disease severity.
Methods.
A total of 109 lgAV patients and 76 age- and sex-matched healthy controls were included.
The age and gender of the study participants were matched.
ApoM levels were measured by an enzyme-linked immunosorbent assay.
Additionally, the serum levels of lipids, apolipoproteins, kidney biochemical profiles, immunoglobulins (IgA, IgG, IgM, and IgE), and the complements (C3 and C4) were assessed using an automatic biochemical analyzer.
Results.
ApoM was increased significantly in lgAV patients compared to healthy controls.
ApoM, meanwhile, was lower in patients with nephritis than in those without nephritis.
The apoM levels were higher in classes I and II IgA vasculitis nephritis (lgAVN) patients than in classes III and IV.
Besides, the apoM serum level<24.81 mg/L was an independent predictive factor for lgAVN and can be independently associated with the presence of nephritis in lgAV patients.
Meanwhile, the serum apoM concentration negatively correlated with the ISKDC grading score in lgAVN patients.
Conclusions.
Serum apoM was elevated in lgAV patients and decreased gradually with the ISKDC grading score.
ApoM (OR=0.32, 95%CI=0.12‐0.85, p=0.023) was identified as a protective factor for nephritis in all lgAV patients.
American Psychological Association (APA)
Wu, Jiali& He, Lagu& Bai, Le& Tan, Li& Hu, Min. 2019. Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146917
Modern Language Association (MLA)
Wu, Jiali…[et al.]. Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146917
American Medical Association (AMA)
Wu, Jiali& He, Lagu& Bai, Le& Tan, Li& Hu, Min. Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146917