Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance

الملخص EN

Background.

Gastric cancer (GC) has a poor prognosis due to the lack of ideal tumor markers.

Circular RNAs (circRNAs) are a novel type of noncoding RNA related to the occurrence of GC.

Among our research, we investigated the role of hsa_circ_0005556 in GC.

Materials and Methods.

The expression of hsa_circ_0005556 of 100 paired GC tissues and adjacent normal tissues was detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

A receiver operating characteristic (ROC) curve was established to evaluate the diagnostic value of hsa_circ_0005556.

The correlation between the expression of hsa_circ_0005556 and corresponding clinicopathological characteristic was explored.

Results.

hsa_circ_0005556 was significantly downregulated in GC tissues contrasted with adjacent normal tissues (n=100, p<0.001).

The areas under the ROC curve (AUC) of hsa_circ_0005556 were up to 0.773, while 64% sensitivity and 82% specificity, respectively.

Moreover, its expression levels were significantly associated with differentiation (p=0.001), TNM stage (p=0.013), and lymphatic metastasis (p=0.039).

GC patients of high hsa_circ_0005556 levels had a longer overall survival (OS) than those of the low group (p=0.047).

Conclusion.

hsa_circ_0005556 is a potential biomarker for GC, which may guide judgment of the indication of endoscopic treatment for early gastric cancer (EGC).