Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance
Joint Authors
Ying, Shibo
Yang, Liangwei
Yu, Yu
Yu, Xiuchong
Zhou, Jiaming
Zhang, Zhiping
Guo, Junming
Yan, Zhilong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Gastric cancer (GC) has a poor prognosis due to the lack of ideal tumor markers.
Circular RNAs (circRNAs) are a novel type of noncoding RNA related to the occurrence of GC.
Among our research, we investigated the role of hsa_circ_0005556 in GC.
Materials and Methods.
The expression of hsa_circ_0005556 of 100 paired GC tissues and adjacent normal tissues was detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
A receiver operating characteristic (ROC) curve was established to evaluate the diagnostic value of hsa_circ_0005556.
The correlation between the expression of hsa_circ_0005556 and corresponding clinicopathological characteristic was explored.
Results.
hsa_circ_0005556 was significantly downregulated in GC tissues contrasted with adjacent normal tissues (n=100, p<0.001).
The areas under the ROC curve (AUC) of hsa_circ_0005556 were up to 0.773, while 64% sensitivity and 82% specificity, respectively.
Moreover, its expression levels were significantly associated with differentiation (p=0.001), TNM stage (p=0.013), and lymphatic metastasis (p=0.039).
GC patients of high hsa_circ_0005556 levels had a longer overall survival (OS) than those of the low group (p=0.047).
Conclusion.
hsa_circ_0005556 is a potential biomarker for GC, which may guide judgment of the indication of endoscopic treatment for early gastric cancer (EGC).
American Psychological Association (APA)
Yang, Liangwei& Yu, Yu& Yu, Xiuchong& Zhou, Jiaming& Zhang, Zhiping& Ying, Shibo…[et al.]. 2019. Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146995
Modern Language Association (MLA)
Yang, Liangwei…[et al.]. Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146995
American Medical Association (AMA)
Yang, Liangwei& Yu, Yu& Yu, Xiuchong& Zhou, Jiaming& Zhang, Zhiping& Ying, Shibo…[et al.]. Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146995