Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain

الملخص EN

Introduction.

Statin-associated muscle symptoms are common side effects of statin therapy.

These symptoms include myopathy, myalgia, and rhabdomyolysis.

Vitamin D has been associated with musculoskeletal health; thus, its deficiency may produce detrimental effects in this tissue.

Indeed, one symptom of vitamin D deficiency is myalgia, and the normalization of low vitamin D levels can relieve it.

Patients and Methods.

This cross-sectional study examined 1210 statin-treated patients to assess vitamin D status.

These patients were divided into two groups: 287 with statin-associated muscle symptoms (SAMS) and 923 control patients without SAMS.

Results.

We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS).

Vitamin D deficiency (<30 nmol/L) presents 77% (95% C.I.

71.6% to 81.7%) sensitivity and 63.4% (95% C.I.

60.2% to 66.5%) specificity in diagnosing SAMS.

Odds ratio analysis showed that this association is moderate-strong both for deficient and for insufficient status.

Conclusion.

We found a correlation between vitamin D deficiency and SAMS.

Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.