Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain
Joint Authors
Lanza, Giuseppe
Bella, Rita
Pennisi, Manuela
Di Bartolo, Giuseppe
Malaguarnera, Giulia
Malaguarnera, Michele
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Statin-associated muscle symptoms are common side effects of statin therapy.
These symptoms include myopathy, myalgia, and rhabdomyolysis.
Vitamin D has been associated with musculoskeletal health; thus, its deficiency may produce detrimental effects in this tissue.
Indeed, one symptom of vitamin D deficiency is myalgia, and the normalization of low vitamin D levels can relieve it.
Patients and Methods.
This cross-sectional study examined 1210 statin-treated patients to assess vitamin D status.
These patients were divided into two groups: 287 with statin-associated muscle symptoms (SAMS) and 923 control patients without SAMS.
Results.
We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS).
Vitamin D deficiency (<30 nmol/L) presents 77% (95% C.I.
71.6% to 81.7%) sensitivity and 63.4% (95% C.I.
60.2% to 66.5%) specificity in diagnosing SAMS.
Odds ratio analysis showed that this association is moderate-strong both for deficient and for insufficient status.
Conclusion.
We found a correlation between vitamin D deficiency and SAMS.
Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.
American Psychological Association (APA)
Pennisi, Manuela& Di Bartolo, Giuseppe& Malaguarnera, Giulia& Bella, Rita& Lanza, Giuseppe& Malaguarnera, Michele. 2019. Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain. Disease Markers،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147065
Modern Language Association (MLA)
Pennisi, Manuela…[et al.]. Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain. Disease Markers No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1147065
American Medical Association (AMA)
Pennisi, Manuela& Di Bartolo, Giuseppe& Malaguarnera, Giulia& Bella, Rita& Lanza, Giuseppe& Malaguarnera, Michele. Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147065