Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population

المؤلفون المشاركون

Zhou, Bin
Li, Qin
Zhang, Peng
Zhang, Yan
Li, Kai
Song, Yaping
Su, Min
Zhang, Lin
Wang, Yan Yun

المصدر

Disease Markers

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-04-15

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Previous evidence has indicated that the reduction of axis inhibition protein 1 (AXIN1) expression is related with the poor differentiation of non-small-cell lung cancer (NSCLC).

However, the potential association between AXIN1 and bladder cancer (BC) is unknown.

We aimed to initially explore the relevance of AXIN1 gene polymorphisms (rs12921862 C/A, rs1805105 T/C, and rs370681 C/T) and BC.

Methods.

Three hundred and sixteen BC patients and 419 healthy controls had been enrolled.

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping three tag single-nucleotide polymorphisms (SNPs) of AXIN1.

The SNPstats online analysis software and SPSS software were used for statistical analysis.

Results.

Our data revealed that three tag SNPs were associated with an increased risk of BC (rs12921862: P<0.001, OR 95%CI=4.61 (3.13-6.81); rs1805105: P=0.046, OR 95%CI=1.35 (1.00-1.82); and rs370681: P=0.004, OR 95%CI=1.56 (1.15-2.10)).

For rs12921862, A allele was an independently protective factor which correlated with a better prognosis in non-muscle-invasive bladder cancer (NMIBC) patients (P=0.03, OR 95%CI=0.10 (0.01-0.84)).

Stratification analysis demonstrated that rs370681 polymorphism was related with high-grade bladder cancer (P=0.04, OR 95%CI=1.85 (1.04-3.23)).

Conclusion.

The AXIN1 gene polymorphisms might implicate in BC risk, and rs12921862 could be a potential forecasting factor for prognosis of BC patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Qin& Zhang, Peng& Wang, Yan Yun& Zhang, Yan& Li, Kai& Song, Yaping…[et al.]. 2019. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147153

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Qin…[et al.]. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147153

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Qin& Zhang, Peng& Wang, Yan Yun& Zhang, Yan& Li, Kai& Song, Yaping…[et al.]. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147153

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1147153