Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population
Joint Authors
Zhou, Bin
Li, Qin
Zhang, Peng
Zhang, Yan
Li, Kai
Song, Yaping
Su, Min
Zhang, Lin
Wang, Yan Yun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Previous evidence has indicated that the reduction of axis inhibition protein 1 (AXIN1) expression is related with the poor differentiation of non-small-cell lung cancer (NSCLC).
However, the potential association between AXIN1 and bladder cancer (BC) is unknown.
We aimed to initially explore the relevance of AXIN1 gene polymorphisms (rs12921862 C/A, rs1805105 T/C, and rs370681 C/T) and BC.
Methods.
Three hundred and sixteen BC patients and 419 healthy controls had been enrolled.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping three tag single-nucleotide polymorphisms (SNPs) of AXIN1.
The SNPstats online analysis software and SPSS software were used for statistical analysis.
Results.
Our data revealed that three tag SNPs were associated with an increased risk of BC (rs12921862: P<0.001, OR 95%CI=4.61 (3.13-6.81); rs1805105: P=0.046, OR 95%CI=1.35 (1.00-1.82); and rs370681: P=0.004, OR 95%CI=1.56 (1.15-2.10)).
For rs12921862, A allele was an independently protective factor which correlated with a better prognosis in non-muscle-invasive bladder cancer (NMIBC) patients (P=0.03, OR 95%CI=0.10 (0.01-0.84)).
Stratification analysis demonstrated that rs370681 polymorphism was related with high-grade bladder cancer (P=0.04, OR 95%CI=1.85 (1.04-3.23)).
Conclusion.
The AXIN1 gene polymorphisms might implicate in BC risk, and rs12921862 could be a potential forecasting factor for prognosis of BC patients.
American Psychological Association (APA)
Li, Qin& Zhang, Peng& Wang, Yan Yun& Zhang, Yan& Li, Kai& Song, Yaping…[et al.]. 2019. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147153
Modern Language Association (MLA)
Li, Qin…[et al.]. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147153
American Medical Association (AMA)
Li, Qin& Zhang, Peng& Wang, Yan Yun& Zhang, Yan& Li, Kai& Song, Yaping…[et al.]. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147153