Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma
المؤلفون المشاركون
Wang, Rui-tao
Wang, Xin
Li, Ming-ming
Niu, Ye
Zhang, Xin
Yin, Ji-bin
Zhao, Chang-jiu
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The gut microbiota is involved in the occurrence and development of chronic liver diseases.
Zonulin is considered a marker of intestinal permeability.
The purpose of this study was to assess zonulin levels in patients with chronic hepatitis B (CHB), HBV-associated liver cirrhosis (LC), and HBV-associated hepatocellular carcinoma (HCC).
Materials and Methods.
The study population consisted of 90 HBV-associated HCC patients, 90 HBV-associated LC patients, 90 CHB patients, and 90 healthy subjects.
Serum levels of zonulin and AFP were determined.
The diagnostic accuracy of each marker was evaluated using receiver operating characteristic (ROC) curve analysis (AUC).
Results.
Serum zonulin levels were significantly higher in patients with HCC than in patients with LC or CHB or healthy subjects (p<0.001).
Moreover, the zonulin levels were increased in the advanced stage of LC and HCC.
ROC curve analysis revealed that serum zonulin could be used to differentiate CHB from cirrhosis.
In addition, the combination of zonulin and AFP exhibited a significantly larger AUC compared with zonulin or AFP alone.
Conclusions.
Serum zonulin levels were significantly increased both in LC and in HCC and correlated with the advanced stage of LC and HCC.
Moreover, the combination of zonulin and AFP confers significant benefit to diagnostic accuracy in differentiating LC from HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xin& Li, Ming-ming& Niu, Ye& Zhang, Xin& Yin, Ji-bin& Zhao, Chang-jiu…[et al.]. 2019. Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. Disease Markers،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147484
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xin…[et al.]. Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. Disease Markers No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1147484
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xin& Li, Ming-ming& Niu, Ye& Zhang, Xin& Yin, Ji-bin& Zhao, Chang-jiu…[et al.]. Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147484
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147484
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر