Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma
Joint Authors
Wang, Rui-tao
Wang, Xin
Li, Ming-ming
Niu, Ye
Zhang, Xin
Yin, Ji-bin
Zhao, Chang-jiu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The gut microbiota is involved in the occurrence and development of chronic liver diseases.
Zonulin is considered a marker of intestinal permeability.
The purpose of this study was to assess zonulin levels in patients with chronic hepatitis B (CHB), HBV-associated liver cirrhosis (LC), and HBV-associated hepatocellular carcinoma (HCC).
Materials and Methods.
The study population consisted of 90 HBV-associated HCC patients, 90 HBV-associated LC patients, 90 CHB patients, and 90 healthy subjects.
Serum levels of zonulin and AFP were determined.
The diagnostic accuracy of each marker was evaluated using receiver operating characteristic (ROC) curve analysis (AUC).
Results.
Serum zonulin levels were significantly higher in patients with HCC than in patients with LC or CHB or healthy subjects (p<0.001).
Moreover, the zonulin levels were increased in the advanced stage of LC and HCC.
ROC curve analysis revealed that serum zonulin could be used to differentiate CHB from cirrhosis.
In addition, the combination of zonulin and AFP exhibited a significantly larger AUC compared with zonulin or AFP alone.
Conclusions.
Serum zonulin levels were significantly increased both in LC and in HCC and correlated with the advanced stage of LC and HCC.
Moreover, the combination of zonulin and AFP confers significant benefit to diagnostic accuracy in differentiating LC from HCC.
American Psychological Association (APA)
Wang, Xin& Li, Ming-ming& Niu, Ye& Zhang, Xin& Yin, Ji-bin& Zhao, Chang-jiu…[et al.]. 2019. Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. Disease Markers،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147484
Modern Language Association (MLA)
Wang, Xin…[et al.]. Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. Disease Markers No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1147484
American Medical Association (AMA)
Wang, Xin& Li, Ming-ming& Niu, Ye& Zhang, Xin& Yin, Ji-bin& Zhao, Chang-jiu…[et al.]. Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147484