Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer
المؤلفون المشاركون
Huang, Chumei
Ye, Zhuangjian
Wan, Jianxin
Liang, Jianbo
Liu, Min
Xu, Xiangdong
Li, Laisheng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Secreted frizzled-related protein 2 (sFRP2) is a secreted protein associated with cancer drug resistance and metastasis.
However, few studies have reported serum sFRP2 levels in breast cancer.
We evaluated serum sFRP2 as a potential biomarker for breast cancer.
Methods.
Serum sFRP2 concentrations were detected in 274 breast cancer patients along with 147 normal healthy controls by enzyme-linked immunosorbent assay (ELISA).
Diagnostic significance was evaluated by area under the curve (AUC) analysis and the Youden index.
Prognostic significance was determined by Kaplan-Meier survival method and univariate and multivariate Cox proportional hazard regression model analyses.
Results.
Serum sFRP2 was elevated in breast cancer patients compared to normal healthy controls (P<0.001).
The sensitivity of sFRP2 in diagnosing breast cancer was 76.9% at a specificity of 76.6%.
Elevated serum sFRP2 levels are associated with primary tumor size, TNM stage, and lymph node metastases.
The Kaplan-Meier curves showed a significant association of serum sFRP2 with progression-free survival.
The multivariate Cox analysis confirmed that high serum sFRP2 was an independent prognostic factor for poor prognosis (HR=3.89, 95% CI=1.95-7.68, P=0.001).
Conclusions.
In conclusion, serum sFRP2 may serve as a potential biomarker for breast cancer diagnosis and prognostic evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Chumei& Ye, Zhuangjian& Wan, Jianxin& Liang, Jianbo& Liu, Min& Xu, Xiangdong…[et al.]. 2019. Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Chumei…[et al.]. Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Chumei& Ye, Zhuangjian& Wan, Jianxin& Liang, Jianbo& Liu, Min& Xu, Xiangdong…[et al.]. Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر