Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer

Abstract EN

Purpose.

Secreted frizzled-related protein 2 (sFRP2) is a secreted protein associated with cancer drug resistance and metastasis.

However, few studies have reported serum sFRP2 levels in breast cancer.

We evaluated serum sFRP2 as a potential biomarker for breast cancer.

Methods.

Serum sFRP2 concentrations were detected in 274 breast cancer patients along with 147 normal healthy controls by enzyme-linked immunosorbent assay (ELISA).

Diagnostic significance was evaluated by area under the curve (AUC) analysis and the Youden index.

Prognostic significance was determined by Kaplan-Meier survival method and univariate and multivariate Cox proportional hazard regression model analyses.

Results.

Serum sFRP2 was elevated in breast cancer patients compared to normal healthy controls (P<0.001).

The sensitivity of sFRP2 in diagnosing breast cancer was 76.9% at a specificity of 76.6%.

Elevated serum sFRP2 levels are associated with primary tumor size, TNM stage, and lymph node metastases.

The Kaplan-Meier curves showed a significant association of serum sFRP2 with progression-free survival.

The multivariate Cox analysis confirmed that high serum sFRP2 was an independent prognostic factor for poor prognosis (HR=3.89, 95% CI=1.95-7.68, P=0.001).

Conclusions.

In conclusion, serum sFRP2 may serve as a potential biomarker for breast cancer diagnosis and prognostic evaluation.