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De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study
المؤلفون المشاركون
Kim, Hyeon Hoe
Kwak, Cheol
Ku, Ja Hyeon
Yuk, Hyeong Dong
Jeong, Chang Wook
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
To investigate the correlation between preoperative De Ritis ratio (aspartate transaminase (AST)/alanine transaminase (ALT)) and postoperative outcome in patients with urothelial cell carcinoma (UC) treated with radical cystectomy.
Materials and Methods.
We analyzed the clinical and pathological data of 771 patients who underwent radical cystectomy for bladder UC.
Patients were divided into two groups according to the optimal value of AST/ALT ratio.
The effect of the AST/ALT ratio was analyzed using the Kaplan–Meier method and Cox regression hazard models for patients’ cancer-specific survival (CSS), overall survival (OS), and recurrence-free survival (RFS).
In addition, propensity score matching of 1 : 1 was performed between the two groups.
Results.
Median follow-up was 84.0 (36–275) months.
Mean age was 64.8±10.0 years.
According to the receiver operating characteristic (ROC) analysis, the optimal threshold of the AST/ALT ratio was 1.1.
In Kaplan–Meier analyses, the high AST/ALT group showed worse outcomes in CSS and OS (all P<0.001).
Also, RFS (P=0.001) in the Cox regression models of clinical and pathological parameters was used to predict CSS, OS, and AST/ALT ratio (HR 2.15, 95% CI 1.23-3.73, P=0.007) and pathological T stage (HR 4.80, 95% CI 1.19-19.28, P=0.003).
To predict OS and AST/ALT ratio (HR 2.05, 95% CI 1.65–2.56, P<0.001), pathological T stage (HR 2.96, 95% CI 0.57–17.09, P=0.037) and positive lymph node (HR 1.71, 95% CI 1.50–1.91, P=0.021) were determined as independent prognostic factors.
Conclusion.
Preoperative AST/ALT ratio could be an independent prognostic factor in patients with UC treated with radical cystectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuk, Hyeong Dong& Jeong, Chang Wook& Kwak, Cheol& Kim, Hyeon Hoe& Ku, Ja Hyeon. 2019. De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147604
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuk, Hyeong Dong…[et al.]. De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147604
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuk, Hyeong Dong& Jeong, Chang Wook& Kwak, Cheol& Kim, Hyeon Hoe& Ku, Ja Hyeon. De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147604
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147604
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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