De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study
Joint Authors
Kim, Hyeon Hoe
Kwak, Cheol
Ku, Ja Hyeon
Yuk, Hyeong Dong
Jeong, Chang Wook
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
To investigate the correlation between preoperative De Ritis ratio (aspartate transaminase (AST)/alanine transaminase (ALT)) and postoperative outcome in patients with urothelial cell carcinoma (UC) treated with radical cystectomy.
Materials and Methods.
We analyzed the clinical and pathological data of 771 patients who underwent radical cystectomy for bladder UC.
Patients were divided into two groups according to the optimal value of AST/ALT ratio.
The effect of the AST/ALT ratio was analyzed using the Kaplan–Meier method and Cox regression hazard models for patients’ cancer-specific survival (CSS), overall survival (OS), and recurrence-free survival (RFS).
In addition, propensity score matching of 1 : 1 was performed between the two groups.
Results.
Median follow-up was 84.0 (36–275) months.
Mean age was 64.8±10.0 years.
According to the receiver operating characteristic (ROC) analysis, the optimal threshold of the AST/ALT ratio was 1.1.
In Kaplan–Meier analyses, the high AST/ALT group showed worse outcomes in CSS and OS (all P<0.001).
Also, RFS (P=0.001) in the Cox regression models of clinical and pathological parameters was used to predict CSS, OS, and AST/ALT ratio (HR 2.15, 95% CI 1.23-3.73, P=0.007) and pathological T stage (HR 4.80, 95% CI 1.19-19.28, P=0.003).
To predict OS and AST/ALT ratio (HR 2.05, 95% CI 1.65–2.56, P<0.001), pathological T stage (HR 2.96, 95% CI 0.57–17.09, P=0.037) and positive lymph node (HR 1.71, 95% CI 1.50–1.91, P=0.021) were determined as independent prognostic factors.
Conclusion.
Preoperative AST/ALT ratio could be an independent prognostic factor in patients with UC treated with radical cystectomy.
American Psychological Association (APA)
Yuk, Hyeong Dong& Jeong, Chang Wook& Kwak, Cheol& Kim, Hyeon Hoe& Ku, Ja Hyeon. 2019. De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147604
Modern Language Association (MLA)
Yuk, Hyeong Dong…[et al.]. De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147604
American Medical Association (AMA)
Yuk, Hyeong Dong& Jeong, Chang Wook& Kwak, Cheol& Kim, Hyeon Hoe& Ku, Ja Hyeon. De Ritis Ratio (Aspartate TransaminaseAlanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147604