Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report
المؤلفون المشاركون
Nemr, Saed
Alluri, Sunitha
Sundaramurthy, Dhivya
Landry, Daniel
Braden, Gregory
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-02
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Calcitriol-mediated hypercalcemia has been reported in malignant lymphomas and granulomatous diseases but not in lung carcinoma.
We describe a patient with squamous cell lung carcinoma with hypercalcemia and elevated calcitriol levels.
A 60-year-old Caucasian male patient with stage IIIB squamous cell lung cancer developed hypercalcemia at 14.8 mg/dL two years after receiving chemotherapy and radiotherapy where labs showed a serum intact PTH: 7 pg/mL, PTHrP: 30 pmol/L, 1,25-hydroxyvitamin D (calcitriol): 76 pg/mL, and 25-hydroxyvitamin D levels: <4 ng/mL.
Calcitriol levels were elevated despite undetectable 25-hydroxyvitamin D levels.
There are no reported lung cancer cases with elevated calcitriol as an etiology of hypercalcemia.
We believe that the elevated calcitriol levels in this case were due to a PTHrP-independent mechanism, possibly from either ectopic production of calcitriol in tumor cells or from increased activity of 1-alpha hydroxylase in the same cells.
The patient died before the effects of prednisone therapy could be assessed.
Studies are needed to investigate the cellular source of calcitriol and its role in hypercalcemia in patients with lung cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nemr, Saed& Alluri, Sunitha& Sundaramurthy, Dhivya& Landry, Daniel& Braden, Gregory. 2017. Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147635
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nemr, Saed…[et al.]. Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147635
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nemr, Saed& Alluri, Sunitha& Sundaramurthy, Dhivya& Landry, Daniel& Braden, Gregory. Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147635
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147635
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر