Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report
Joint Authors
Nemr, Saed
Alluri, Sunitha
Sundaramurthy, Dhivya
Landry, Daniel
Braden, Gregory
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-02
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Calcitriol-mediated hypercalcemia has been reported in malignant lymphomas and granulomatous diseases but not in lung carcinoma.
We describe a patient with squamous cell lung carcinoma with hypercalcemia and elevated calcitriol levels.
A 60-year-old Caucasian male patient with stage IIIB squamous cell lung cancer developed hypercalcemia at 14.8 mg/dL two years after receiving chemotherapy and radiotherapy where labs showed a serum intact PTH: 7 pg/mL, PTHrP: 30 pmol/L, 1,25-hydroxyvitamin D (calcitriol): 76 pg/mL, and 25-hydroxyvitamin D levels: <4 ng/mL.
Calcitriol levels were elevated despite undetectable 25-hydroxyvitamin D levels.
There are no reported lung cancer cases with elevated calcitriol as an etiology of hypercalcemia.
We believe that the elevated calcitriol levels in this case were due to a PTHrP-independent mechanism, possibly from either ectopic production of calcitriol in tumor cells or from increased activity of 1-alpha hydroxylase in the same cells.
The patient died before the effects of prednisone therapy could be assessed.
Studies are needed to investigate the cellular source of calcitriol and its role in hypercalcemia in patients with lung cancer.
American Psychological Association (APA)
Nemr, Saed& Alluri, Sunitha& Sundaramurthy, Dhivya& Landry, Daniel& Braden, Gregory. 2017. Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147635
Modern Language Association (MLA)
Nemr, Saed…[et al.]. Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147635
American Medical Association (AMA)
Nemr, Saed& Alluri, Sunitha& Sundaramurthy, Dhivya& Landry, Daniel& Braden, Gregory. Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147635