Association between MIC-1 and Type 2 Diabetes: A Combined Analysis
المؤلفون المشاركون
Qin, Liqiang
Lu, Jianan
Zhang, Yue
Dong, Xingxuan
Lu, Jiawen
Zhang, Chen
Liu, Jieyu
Yu, Qingzhou
Teng, Haoyue
Yao, Qingkui
Yin, Jieyun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Objectives.
Type 2 diabetes mellitus (T2DM) is an epidemic disease that endangers human health seriously.
Recently, a large number of reports have revealed that macrophage-inhibiting cytokine-1 (MIC-1) is linked with T2DM, but the results were inconclusive.
The aim of this study was to perform bioinformatics analysis of the association between MIC-1 and T2DM.
Material and Methods.
Datasets and relevant literatures were searched in Gene Expression Omnibus (GEO), PubMed, Google Scholar, and Web of Science till September 20, 2019.
Expression levels of MIC-1 were extracted, pooled, and compared between T2DM cases and controls.
Results.
In summary, 11 GEO datasets and 3 articles with 421 T2DM cases and 711 controls were finally included.
The expression level of MIC-1 was significantly higher in T2DM patients compared with controls, with a standard mean difference (SMD) of 0.54 and a 95% confidence interval (95% CI) of 0.24-0.83; in blood samples, the difference was still significant (SMD=0.65; 95%CI=0.24‐1.06).
Meanwhile, the expression level of MIC-1 plays a significant role in differentiating T2DM cases from controls; the combined sensitivity, specificity, and odds ratio were 0.83 (95%CI=0.72‐0.90), 0.59 (95%CI=0.45‐0.72), and 1.64 (95%CI=1.35‐1.99), respectively.
The summary receiver operating characteristic (SROC) curve demonstrated that the area under the curve (AUC) was 0.81 (95%CI=0.77‐0.84).
Conclusion.
Our results suggested that the expression levels of MIC-1 were significantly higher in T2DM patients in multiple tissues including blood samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Jianan& Zhang, Yue& Dong, Xingxuan& Lu, Jiawen& Zhang, Chen& Liu, Jieyu…[et al.]. 2019. Association between MIC-1 and Type 2 Diabetes: A Combined Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Jianan…[et al.]. Association between MIC-1 and Type 2 Diabetes: A Combined Analysis. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Jianan& Zhang, Yue& Dong, Xingxuan& Lu, Jiawen& Zhang, Chen& Liu, Jieyu…[et al.]. Association between MIC-1 and Type 2 Diabetes: A Combined Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر