Association between MIC-1 and Type 2 Diabetes: A Combined Analysis
Joint Authors
Qin, Liqiang
Lu, Jianan
Zhang, Yue
Dong, Xingxuan
Lu, Jiawen
Zhang, Chen
Liu, Jieyu
Yu, Qingzhou
Teng, Haoyue
Yao, Qingkui
Yin, Jieyun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Objectives.
Type 2 diabetes mellitus (T2DM) is an epidemic disease that endangers human health seriously.
Recently, a large number of reports have revealed that macrophage-inhibiting cytokine-1 (MIC-1) is linked with T2DM, but the results were inconclusive.
The aim of this study was to perform bioinformatics analysis of the association between MIC-1 and T2DM.
Material and Methods.
Datasets and relevant literatures were searched in Gene Expression Omnibus (GEO), PubMed, Google Scholar, and Web of Science till September 20, 2019.
Expression levels of MIC-1 were extracted, pooled, and compared between T2DM cases and controls.
Results.
In summary, 11 GEO datasets and 3 articles with 421 T2DM cases and 711 controls were finally included.
The expression level of MIC-1 was significantly higher in T2DM patients compared with controls, with a standard mean difference (SMD) of 0.54 and a 95% confidence interval (95% CI) of 0.24-0.83; in blood samples, the difference was still significant (SMD=0.65; 95%CI=0.24‐1.06).
Meanwhile, the expression level of MIC-1 plays a significant role in differentiating T2DM cases from controls; the combined sensitivity, specificity, and odds ratio were 0.83 (95%CI=0.72‐0.90), 0.59 (95%CI=0.45‐0.72), and 1.64 (95%CI=1.35‐1.99), respectively.
The summary receiver operating characteristic (SROC) curve demonstrated that the area under the curve (AUC) was 0.81 (95%CI=0.77‐0.84).
Conclusion.
Our results suggested that the expression levels of MIC-1 were significantly higher in T2DM patients in multiple tissues including blood samples.
American Psychological Association (APA)
Lu, Jianan& Zhang, Yue& Dong, Xingxuan& Lu, Jiawen& Zhang, Chen& Liu, Jieyu…[et al.]. 2019. Association between MIC-1 and Type 2 Diabetes: A Combined Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147694
Modern Language Association (MLA)
Lu, Jianan…[et al.]. Association between MIC-1 and Type 2 Diabetes: A Combined Analysis. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147694
American Medical Association (AMA)
Lu, Jianan& Zhang, Yue& Dong, Xingxuan& Lu, Jiawen& Zhang, Chen& Liu, Jieyu…[et al.]. Association between MIC-1 and Type 2 Diabetes: A Combined Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147694