Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Wang, Fang-Ming
Zhang, Guiming
Liu, Wen
Sun, Lijiang
Guan, Fengju
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-03
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
This study was performed to identify the prognostic impact of lymphovascular invasion (LVI) in patients with upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU).
A systematic search in PubMed, Embase, and the Cochrane Library was performed to identify relevant studies.
The outcomes of interest, including progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS), were extracted, and the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used for effect size estimation.
Subgroup, metaregression, and sensitivity analyses were performed to explore potential origins of heterogeneity.
Publication bias was estimated by Egger’s linear regression and funnel plot.
Our meta-analysis included a total of 27 studies involving 17,453 patients.
The pooled HRs were statistically significant for PFS (HR=1.73, 95%CI=1.41–2.11), CSS (HR=1.87, 95%CI=1.54–2.27), and OS (HR=1.56, 95%CI=1.29–1.87), with high heterogeneity (I2=77.8%, 70.3%, and 59.2%, respectively).
Four studies explored the prognostic value of LVI in patients with advanced tumor stages (T3–T4).
The fixed effects model (I2=33.9%) showed that the pooled HR was 1.64 (95%CI=1.35–1.99) for CSS.
Egger’s plots showed no significant publication bias (PFS: P=0.443, CSS: P=0.096, and OS: P=0.894).
Our meta-analysis demonstrated that LVI is a poor prognostic factor for UTUC and is strongly associated with disease recurrence, cancer-specific mortality, and overall mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Wen& Sun, Lijiang& Guan, Fengju& Wang, Fang-Ming& Zhang, Guiming. 2019. Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1147711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Wen…[et al.]. Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1147711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Wen& Sun, Lijiang& Guan, Fengju& Wang, Fang-Ming& Zhang, Guiming. Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1147711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر