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Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Fang-Ming
Zhang, Guiming
Liu, Wen
Sun, Lijiang
Guan, Fengju
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
This study was performed to identify the prognostic impact of lymphovascular invasion (LVI) in patients with upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU).
A systematic search in PubMed, Embase, and the Cochrane Library was performed to identify relevant studies.
The outcomes of interest, including progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS), were extracted, and the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used for effect size estimation.
Subgroup, metaregression, and sensitivity analyses were performed to explore potential origins of heterogeneity.
Publication bias was estimated by Egger’s linear regression and funnel plot.
Our meta-analysis included a total of 27 studies involving 17,453 patients.
The pooled HRs were statistically significant for PFS (HR=1.73, 95%CI=1.41–2.11), CSS (HR=1.87, 95%CI=1.54–2.27), and OS (HR=1.56, 95%CI=1.29–1.87), with high heterogeneity (I2=77.8%, 70.3%, and 59.2%, respectively).
Four studies explored the prognostic value of LVI in patients with advanced tumor stages (T3–T4).
The fixed effects model (I2=33.9%) showed that the pooled HR was 1.64 (95%CI=1.35–1.99) for CSS.
Egger’s plots showed no significant publication bias (PFS: P=0.443, CSS: P=0.096, and OS: P=0.894).
Our meta-analysis demonstrated that LVI is a poor prognostic factor for UTUC and is strongly associated with disease recurrence, cancer-specific mortality, and overall mortality.
American Psychological Association (APA)
Liu, Wen& Sun, Lijiang& Guan, Fengju& Wang, Fang-Ming& Zhang, Guiming. 2019. Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1147711
Modern Language Association (MLA)
Liu, Wen…[et al.]. Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1147711
American Medical Association (AMA)
Liu, Wen& Sun, Lijiang& Guan, Fengju& Wang, Fang-Ming& Zhang, Guiming. Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1147711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147711