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A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm
المؤلفون المشاركون
Zhu, Wang-Yu
Zhang, Yong-Kui
Le, Han-bo
Fang, Ke-xin
He, Jian-ying
Cui, Ri
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We sought to develop and validate a clinical nomogram model for predicting overall survival (OS) in non-small-cell lung cancer (NSCLC) patients with resected tumors that were 30 mm or smaller, using clinical data and molecular marker findings.
We retrospectively analyzed 786 NSCLC patients with a pathological tumor size less than 30 mm who underwent surgery between 2007 and 2017 at our institution.
We identified and integrated significant prognostic factors to build the nomogram model using the training set, which was subjected to the internal data validation.
The prognostic performance was calibrated and evaluated by the concordance index (C-index) and risk group stratification.
Multivariable analysis identified the pathological tumor size, lymph node metastasis, and Ki-67 expression as independent prognostic factors, which were entered into the nomogram model.
The nomogram-predicted probabilities of OS at 1 year, 3 years, and 5 years posttreatment represented optimal concordance with the actual observations.
Harrell’s C-index of the constructed nomogram with the training set was 0.856 (95% CI: 0.804-0.908), whereas TNM staging was 0.814 (95% CI: 0.742-0.886, P=5.280221e−13).
Survival analysis demonstrated that NSCLC subgroups showed significant differences in the training and validation sets (P<0.001).
A nomogram model was established for predicting survival in NSCLC patients with a pathological tumor size less than 30 mm, which would be further validated using demographic and clinicopathological data.
In the future, this prognostic model may assist clinicians during treatment planning and clinical studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Wang-Yu& Fang, Ke-xin& He, Jian-ying& Cui, Ri& Zhang, Yong-Kui& Le, Han-bo. 2019. A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147871
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Wang-Yu…[et al.]. A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147871
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Wang-Yu& Fang, Ke-xin& He, Jian-ying& Cui, Ri& Zhang, Yong-Kui& Le, Han-bo. A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147871
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147871
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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