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A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm
Joint Authors
Zhu, Wang-Yu
Zhang, Yong-Kui
Le, Han-bo
Fang, Ke-xin
He, Jian-ying
Cui, Ri
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We sought to develop and validate a clinical nomogram model for predicting overall survival (OS) in non-small-cell lung cancer (NSCLC) patients with resected tumors that were 30 mm or smaller, using clinical data and molecular marker findings.
We retrospectively analyzed 786 NSCLC patients with a pathological tumor size less than 30 mm who underwent surgery between 2007 and 2017 at our institution.
We identified and integrated significant prognostic factors to build the nomogram model using the training set, which was subjected to the internal data validation.
The prognostic performance was calibrated and evaluated by the concordance index (C-index) and risk group stratification.
Multivariable analysis identified the pathological tumor size, lymph node metastasis, and Ki-67 expression as independent prognostic factors, which were entered into the nomogram model.
The nomogram-predicted probabilities of OS at 1 year, 3 years, and 5 years posttreatment represented optimal concordance with the actual observations.
Harrell’s C-index of the constructed nomogram with the training set was 0.856 (95% CI: 0.804-0.908), whereas TNM staging was 0.814 (95% CI: 0.742-0.886, P=5.280221e−13).
Survival analysis demonstrated that NSCLC subgroups showed significant differences in the training and validation sets (P<0.001).
A nomogram model was established for predicting survival in NSCLC patients with a pathological tumor size less than 30 mm, which would be further validated using demographic and clinicopathological data.
In the future, this prognostic model may assist clinicians during treatment planning and clinical studies.
American Psychological Association (APA)
Zhu, Wang-Yu& Fang, Ke-xin& He, Jian-ying& Cui, Ri& Zhang, Yong-Kui& Le, Han-bo. 2019. A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147871
Modern Language Association (MLA)
Zhu, Wang-Yu…[et al.]. A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147871
American Medical Association (AMA)
Zhu, Wang-Yu& Fang, Ke-xin& He, Jian-ying& Cui, Ri& Zhang, Yong-Kui& Le, Han-bo. A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147871