Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature

الملخص EN

Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer.

Crizotinib-induced hepatotoxicity is a rare event.

We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months.

The medication was discontinued, and she was treated with N-acetylcysteine for seven days.

Her liver function tests returned to normal limits after 26 days after admission.

The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown.

Physicians should be aware of the potentially lethal side effect caused by crizotinib.