A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System
المؤلفون المشاركون
Mascherona, Ilenia
Biggiogero, Maira
Mora, Oreste
Marelli, Lucia
Maggioli, Caterina
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Gemcitabine is an antineoplastic drug used in several forms of advanced pancreatic, lung, breast, ovarian, and bladder cancer.
Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, gastrointestinal upset, rash, alopecia, and stomatitis.
Transient serum enzyme elevations could be observed during therapy, but clinically significant acute liver injury has been rarely associated with its use.
Few cases of acute liver injury have been reported in the literature.
We reported the clinical case of a 73--year-old man who developed clinically significant acute hepatic injury after using gemcitabine.
Possible causes, clinical presentation, and treatments are discussed.
According to the updated RUCAM score, the case was rated 10 points and became a suspected drug-induced liver injury.
Moreover, on the liver biopsy, there were histological findings of mild-to-moderate portal hepatitis, eosinophilia, bile duct injury, and mild perisinusoidal fibrosis, suggesting drug damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mascherona, Ilenia& Maggioli, Caterina& Biggiogero, Maira& Mora, Oreste& Marelli, Lucia. 2020. A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System. Case Reports in Hepatology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147950
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mascherona, Ilenia…[et al.]. A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System. Case Reports in Hepatology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147950
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mascherona, Ilenia& Maggioli, Caterina& Biggiogero, Maira& Mora, Oreste& Marelli, Lucia. A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System. Case Reports in Hepatology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147950
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147950
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر