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A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System
Joint Authors
Mascherona, Ilenia
Biggiogero, Maira
Mora, Oreste
Marelli, Lucia
Maggioli, Caterina
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Gemcitabine is an antineoplastic drug used in several forms of advanced pancreatic, lung, breast, ovarian, and bladder cancer.
Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, gastrointestinal upset, rash, alopecia, and stomatitis.
Transient serum enzyme elevations could be observed during therapy, but clinically significant acute liver injury has been rarely associated with its use.
Few cases of acute liver injury have been reported in the literature.
We reported the clinical case of a 73--year-old man who developed clinically significant acute hepatic injury after using gemcitabine.
Possible causes, clinical presentation, and treatments are discussed.
According to the updated RUCAM score, the case was rated 10 points and became a suspected drug-induced liver injury.
Moreover, on the liver biopsy, there were histological findings of mild-to-moderate portal hepatitis, eosinophilia, bile duct injury, and mild perisinusoidal fibrosis, suggesting drug damage.
American Psychological Association (APA)
Mascherona, Ilenia& Maggioli, Caterina& Biggiogero, Maira& Mora, Oreste& Marelli, Lucia. 2020. A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System. Case Reports in Hepatology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147950
Modern Language Association (MLA)
Mascherona, Ilenia…[et al.]. A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System. Case Reports in Hepatology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147950
American Medical Association (AMA)
Mascherona, Ilenia& Maggioli, Caterina& Biggiogero, Maira& Mora, Oreste& Marelli, Lucia. A Severe Case of Drug-Induced Liver Injury after Gemcitabine Administration: A Highly Probable Causality Grading as Assessed by the Updated RUCAM Diagnostic Scoring System. Case Reports in Hepatology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147950