Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM
المؤلفون المشاركون
Al-Hamoudi, Waleed
Elsiesy, H.
Alenazy, Leila A.
Javed, Muhammad
Raddaoui, Emad
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-13
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Glycogen hepatopathy (GH) is a rare complication of type 1 diabetes mellitus that leads to an abnormal accumulation of glycogen in the hepatocytes.
The exact mechanism of GH remains unknown, but fluctuations in blood glucose and insulin levels play important roles in promoting glycogen accumulation.
We report a case of a 16-year-old female diagnosed with poorly controlled type 1 diabetes mellitus with hepatomegaly and elevated liver enzymes.
The patient experienced multiple admissions for diabetic ketoacidosis, and she also had celiac disease diagnosed 2 years previously based on serology and a duodenal biopsy.
The laboratory analyses results were compatible with acute hepatitis, and the celiac serology was positive.
Other investigations ruled out viral hepatitis and autoimmune and metabolic liver diseases.
Ultrasound and computerized tomography (CT) scans of the abdomen revealed liver enlargement with diffuse fatty infiltration.
A liver biopsy revealed the presence of abundant glycogen in the cytoplasm of the hepatocytes.
PAS staining was strongly positive, which confirmed the diagnosis of GH.
There were no features of autoimmune hepatitis or significant fibrosis.
Duodenal biopsy results were consistent with celiac disease.
Despite our efforts, which are supported by a multidisciplinary team approach that included a hepatologist, a diabetic educator, a dietitian, and an endocrinologist, we have encountered difficulties in controlling the patient’s diabetes, and she persistently maintains symptomatic hepatomegaly and abnormal liver biochemistry.
Given the patient’s age, we assumed that these abnormalities were related to patient noncompliance.
In conclusion, GH remains an under-recognized complication of type 1 DM that is potentially reversible with adequate glycemic control.
The awareness of GH should prevent diagnostic delay and its implications for management and the outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alenazy, Leila A.& Javed, Muhammad& Elsiesy, H.& Raddaoui, Emad& Al-Hamoudi, Waleed. 2020. Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148373
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alenazy, Leila A.…[et al.]. Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM. Case Reports in Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1148373
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alenazy, Leila A.& Javed, Muhammad& Elsiesy, H.& Raddaoui, Emad& Al-Hamoudi, Waleed. Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148373
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148373
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر