Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM
Joint Authors
Al-Hamoudi, Waleed
Elsiesy, H.
Alenazy, Leila A.
Javed, Muhammad
Raddaoui, Emad
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Glycogen hepatopathy (GH) is a rare complication of type 1 diabetes mellitus that leads to an abnormal accumulation of glycogen in the hepatocytes.
The exact mechanism of GH remains unknown, but fluctuations in blood glucose and insulin levels play important roles in promoting glycogen accumulation.
We report a case of a 16-year-old female diagnosed with poorly controlled type 1 diabetes mellitus with hepatomegaly and elevated liver enzymes.
The patient experienced multiple admissions for diabetic ketoacidosis, and she also had celiac disease diagnosed 2 years previously based on serology and a duodenal biopsy.
The laboratory analyses results were compatible with acute hepatitis, and the celiac serology was positive.
Other investigations ruled out viral hepatitis and autoimmune and metabolic liver diseases.
Ultrasound and computerized tomography (CT) scans of the abdomen revealed liver enlargement with diffuse fatty infiltration.
A liver biopsy revealed the presence of abundant glycogen in the cytoplasm of the hepatocytes.
PAS staining was strongly positive, which confirmed the diagnosis of GH.
There were no features of autoimmune hepatitis or significant fibrosis.
Duodenal biopsy results were consistent with celiac disease.
Despite our efforts, which are supported by a multidisciplinary team approach that included a hepatologist, a diabetic educator, a dietitian, and an endocrinologist, we have encountered difficulties in controlling the patient’s diabetes, and she persistently maintains symptomatic hepatomegaly and abnormal liver biochemistry.
Given the patient’s age, we assumed that these abnormalities were related to patient noncompliance.
In conclusion, GH remains an under-recognized complication of type 1 DM that is potentially reversible with adequate glycemic control.
The awareness of GH should prevent diagnostic delay and its implications for management and the outcome.
American Psychological Association (APA)
Alenazy, Leila A.& Javed, Muhammad& Elsiesy, H.& Raddaoui, Emad& Al-Hamoudi, Waleed. 2020. Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148373
Modern Language Association (MLA)
Alenazy, Leila A.…[et al.]. Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM. Case Reports in Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1148373
American Medical Association (AMA)
Alenazy, Leila A.& Javed, Muhammad& Elsiesy, H.& Raddaoui, Emad& Al-Hamoudi, Waleed. Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148373