PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata

المؤلفون المشاركون

Ma, Dujun
Yu, Tian
Peng, Liping
Wang, Lixin
Liao, Zhouwei
Xu, Wenming

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-07-15

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Aim.

Achyranthes bidentata is one of the most commonly used Chinese herbal medicines (CHM) that is currently considered for the treatment of osteoarthritis.

The purpose of this study was to reveal the mechanism of Achyranthes bidentata in osteoarthritis treatment based on the network pharmacology.

Methods.

The effective components of Achyranthes bidentata were firstly screened out from the TCMSP database with ADME property parameters.

Then, osteoarthritis-related proteins targeted by the effective components were predicted based on the DrugBank and CTD databases.

Subsequently, enrichment analysis and interaction network between targets of effective components and pathways were also studied.

In addition, the differentially expressed genes (DEGs) of GSE55457 were used for validation of the osteoarthritis-related target proteins.

Finally, the effective components–target molecular docking models were predicted.

Results.

A total of 10 effective components were identified, of which kaempferol and quercetin had 1 and 29 targets, respectively.

There were 26 target proteins of quercetin related to the osteoarthritis.

These targets were mainly enriched in mitochondrial ATP synthesis coupled proton transport, cellular response to estradiol stimulus, and nitric oxide biosynthetic process.

In addition, there were three common proteins, PIM1, CYP1B1, and HSPA2 based on the DEGs of GSE55457, which were considered as the key targeted proteins of the quercetin.

Conclusion.

The docking of PIM1-quercetin, CYP1B1-quercetin, and HSPA2-quercetin may play important roles during the treatment of osteoarthritis by Achyranthes bidentata.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ma, Dujun& Yu, Tian& Peng, Liping& Wang, Lixin& Liao, Zhouwei& Xu, Wenming. 2019. PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148415

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ma, Dujun…[et al.]. PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1148415

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ma, Dujun& Yu, Tian& Peng, Liping& Wang, Lixin& Liao, Zhouwei& Xu, Wenming. PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148415

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1148415