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PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata
Joint Authors
Ma, Dujun
Yu, Tian
Peng, Liping
Wang, Lixin
Liao, Zhouwei
Xu, Wenming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
Achyranthes bidentata is one of the most commonly used Chinese herbal medicines (CHM) that is currently considered for the treatment of osteoarthritis.
The purpose of this study was to reveal the mechanism of Achyranthes bidentata in osteoarthritis treatment based on the network pharmacology.
Methods.
The effective components of Achyranthes bidentata were firstly screened out from the TCMSP database with ADME property parameters.
Then, osteoarthritis-related proteins targeted by the effective components were predicted based on the DrugBank and CTD databases.
Subsequently, enrichment analysis and interaction network between targets of effective components and pathways were also studied.
In addition, the differentially expressed genes (DEGs) of GSE55457 were used for validation of the osteoarthritis-related target proteins.
Finally, the effective components–target molecular docking models were predicted.
Results.
A total of 10 effective components were identified, of which kaempferol and quercetin had 1 and 29 targets, respectively.
There were 26 target proteins of quercetin related to the osteoarthritis.
These targets were mainly enriched in mitochondrial ATP synthesis coupled proton transport, cellular response to estradiol stimulus, and nitric oxide biosynthetic process.
In addition, there were three common proteins, PIM1, CYP1B1, and HSPA2 based on the DEGs of GSE55457, which were considered as the key targeted proteins of the quercetin.
Conclusion.
The docking of PIM1-quercetin, CYP1B1-quercetin, and HSPA2-quercetin may play important roles during the treatment of osteoarthritis by Achyranthes bidentata.
American Psychological Association (APA)
Ma, Dujun& Yu, Tian& Peng, Liping& Wang, Lixin& Liao, Zhouwei& Xu, Wenming. 2019. PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148415
Modern Language Association (MLA)
Ma, Dujun…[et al.]. PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1148415
American Medical Association (AMA)
Ma, Dujun& Yu, Tian& Peng, Liping& Wang, Lixin& Liao, Zhouwei& Xu, Wenming. PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148415