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Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats
المؤلفون المشاركون
Qiu, Yue
Hu, Jia-liang
Zhao, Chun-cao
Zhang, Ji-quan
Wu, Fei
Ma, Bing-liang
Feng, Yi
Ruan, Ke-feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life.
Aims.
We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis in model rats.
Materials and Methods.
A rat model of RE was established with the steps of half pylorus ligation, cardiotomy, and hydrochloric acid perfusion.
The rats in treatment groups were orally administered with 1.30, 2.60, or 5.20 g/kg ZHG once daily for 28 days.
Histopathological changes of the esophagus were observed with hematoxylin-eosin staining.
The content of total bilirubin and pH in gastric juice was determined.
Esophageal mucosal injury was assessed by macroscopic observation scores, mucosal injury index scores, and esophageal inflammation scores.
The levels of gastrin (GAS), motilin (MTL), and vasoactive intestinal peptide (VIP) in serum were evaluated by using ELISA kits.
Results.
After treatment with ZHG, the body weight of RE rats tended to increase drastically, the macroscopic observation scores of the esophagus mucous membrane decreased (P<0.05), the mucosal injury index scores decreased (P<0.05), the gastric pH values increased (P<0.05), and the levels of serum MTL and VIP decreased (P<0.05).
In addition, the high dose of the ZHG-treated group showed lower serum GAS (P<0.05), while the high and middle doses of the ZHG-treated groups showed lower esophageal inflammation scores (P<0.05).
Conclusions.
ZHG was effective in treating RE in rats due using mechanisms including improving the pH value of gastric contents, decreasing the gastrointestinal hormones (including GAS, MTL, and VIP), and improving the inflammatory damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiu, Yue& Hu, Jia-liang& Zhao, Chun-cao& Zhang, Ji-quan& Wu, Fei& Ma, Bing-liang…[et al.]. 2019. Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiu, Yue…[et al.]. Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1148530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiu, Yue& Hu, Jia-liang& Zhao, Chun-cao& Zhang, Ji-quan& Wu, Fei& Ma, Bing-liang…[et al.]. Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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