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Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats
Joint Authors
Qiu, Yue
Hu, Jia-liang
Zhao, Chun-cao
Zhang, Ji-quan
Wu, Fei
Ma, Bing-liang
Feng, Yi
Ruan, Ke-feng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life.
Aims.
We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis in model rats.
Materials and Methods.
A rat model of RE was established with the steps of half pylorus ligation, cardiotomy, and hydrochloric acid perfusion.
The rats in treatment groups were orally administered with 1.30, 2.60, or 5.20 g/kg ZHG once daily for 28 days.
Histopathological changes of the esophagus were observed with hematoxylin-eosin staining.
The content of total bilirubin and pH in gastric juice was determined.
Esophageal mucosal injury was assessed by macroscopic observation scores, mucosal injury index scores, and esophageal inflammation scores.
The levels of gastrin (GAS), motilin (MTL), and vasoactive intestinal peptide (VIP) in serum were evaluated by using ELISA kits.
Results.
After treatment with ZHG, the body weight of RE rats tended to increase drastically, the macroscopic observation scores of the esophagus mucous membrane decreased (P<0.05), the mucosal injury index scores decreased (P<0.05), the gastric pH values increased (P<0.05), and the levels of serum MTL and VIP decreased (P<0.05).
In addition, the high dose of the ZHG-treated group showed lower serum GAS (P<0.05), while the high and middle doses of the ZHG-treated groups showed lower esophageal inflammation scores (P<0.05).
Conclusions.
ZHG was effective in treating RE in rats due using mechanisms including improving the pH value of gastric contents, decreasing the gastrointestinal hormones (including GAS, MTL, and VIP), and improving the inflammatory damage.
American Psychological Association (APA)
Qiu, Yue& Hu, Jia-liang& Zhao, Chun-cao& Zhang, Ji-quan& Wu, Fei& Ma, Bing-liang…[et al.]. 2019. Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148530
Modern Language Association (MLA)
Qiu, Yue…[et al.]. Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1148530
American Medical Association (AMA)
Qiu, Yue& Hu, Jia-liang& Zhao, Chun-cao& Zhang, Ji-quan& Wu, Fei& Ma, Bing-liang…[et al.]. Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148530