Piper cubeba L. Methanol Extract Has Anti-Inflammatory Activity Targeting SrcSyk via NF-κB Inhibition
المؤلفون المشاركون
Qomaladewi, Nurinanda Prisky
Aziz, Nur
Kim, Mi-Yeon
Cho, Jae Youl
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Piper cubeba L.
is a plant in the Piperaceae family that is generally found in tropical countries and acts as an antioxidant and anti-inflammatory agent.
Unfortunately, the molecular mechanism of the anti-inflammatory activity has not been fully investigated.
In this study, we elucidated the anti-inflammatory mechanism by focusing on NF-κB signaling, which is considered a prototypical inflammatory signaling pathway in both innate and adaptive immune functions.
Cellular activity and the molecular target of Pc-ME were identified in macrophage RAW264.7 cells and HEK293T cells by assessing NO production, cytokine expression by RT-PCR, luciferase gene reporter assay, and protein regulation in cytoplasm by Western blot upon NF-κB activation.
Pc-ME reduced NO production without any cell toxicity; inhibited expression of proinflammatory cytokines such as iNOS and IL-6; downregulated NF-κB activation mediated by both MyD88 and TRIF; and diminished the phosphorylation of IκBα, IKKα/β, Akt, p85, Src, and Syk.
Pc-ME inhibited Syk and Src autophosphorylation during overexpression in HEK cells, which confirmed our hypothesis that Syk and Src were signaling targets of Pc-ME.
These findings indicate that Piper cubeba L.
has anti-inflammatory activity by targeting Src/Syk in the NF-κB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qomaladewi, Nurinanda Prisky& Aziz, Nur& Kim, Mi-Yeon& Cho, Jae Youl. 2019. Piper cubeba L. Methanol Extract Has Anti-Inflammatory Activity Targeting SrcSyk via NF-κB Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148613
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qomaladewi, Nurinanda Prisky…[et al.]. Piper cubeba L. Methanol Extract Has Anti-Inflammatory Activity Targeting SrcSyk via NF-κB Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1148613
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qomaladewi, Nurinanda Prisky& Aziz, Nur& Kim, Mi-Yeon& Cho, Jae Youl. Piper cubeba L. Methanol Extract Has Anti-Inflammatory Activity Targeting SrcSyk via NF-κB Inhibition. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148613
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148613
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر