Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats
المؤلفون المشاركون
Jiang, Yifang
You, Fengming
Zhu, Jie
Zheng, Chuan
Yan, Ran
Zeng, Jinhao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Cryptotanshinone (CTS) was reported to repress a variety of systemic inflammation and alleviate cardiac fibrosis, but it is still unclear whether CTS could prevent radiation-induced lung injury (RILI).
Here, we investigated the effects and underlying mechanisms of CTS on a RILI rat model.
Our data revealed that CTS could efficiently preserve pulmonary function in RILI rats and reduce early pulmonary inflammation infiltration elicited, along with marked decreased levels of IL-6 and IL-10.
Moreover, we found that CTS is superior to prednisone in attenuating collagen deposition and pulmonary fibrosis, in parallel with a marked drop of HYP (a collagen indicator) and α-SMA (a myofibroblast marker).
Mechanistically, CTS inhibited profibrotic signals TGF-β1 and NOX-4 expressions, while enhancing the levels of antifibrotic enzyme MMP-1 in lung tissues.
It is noteworthy that CTS treatment, in consistent with trichrome staining analysis, exhibited a clear advantage over PND in enhancing MMP-1 levels.
However, CTS exhibited little effect on CTGF activation and on COX-2 suppression.
Finally, CTS treatment significantly mitigated the radiation-induced activation of CCL3 and its receptor CCR1.
In summary, CTS treatment could attenuate RILI, especially pulmonary fibrosis, in rats.
The regulation on production and release of inflammatory or fibrotic factors IL-6, IL-10, TGF-β1, NOX-4, and MMP-1, especially MMP-1 and inhibition on CCL3/CCR1 activation, may partly attribute to its attenuating RILI effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Yifang& You, Fengming& Zhu, Jie& Zheng, Chuan& Yan, Ran& Zeng, Jinhao. 2019. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148774
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Yifang…[et al.]. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1148774
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Yifang& You, Fengming& Zhu, Jie& Zheng, Chuan& Yan, Ran& Zeng, Jinhao. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148774
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148774
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر