Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats
Joint Authors
Jiang, Yifang
You, Fengming
Zhu, Jie
Zheng, Chuan
Yan, Ran
Zeng, Jinhao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cryptotanshinone (CTS) was reported to repress a variety of systemic inflammation and alleviate cardiac fibrosis, but it is still unclear whether CTS could prevent radiation-induced lung injury (RILI).
Here, we investigated the effects and underlying mechanisms of CTS on a RILI rat model.
Our data revealed that CTS could efficiently preserve pulmonary function in RILI rats and reduce early pulmonary inflammation infiltration elicited, along with marked decreased levels of IL-6 and IL-10.
Moreover, we found that CTS is superior to prednisone in attenuating collagen deposition and pulmonary fibrosis, in parallel with a marked drop of HYP (a collagen indicator) and α-SMA (a myofibroblast marker).
Mechanistically, CTS inhibited profibrotic signals TGF-β1 and NOX-4 expressions, while enhancing the levels of antifibrotic enzyme MMP-1 in lung tissues.
It is noteworthy that CTS treatment, in consistent with trichrome staining analysis, exhibited a clear advantage over PND in enhancing MMP-1 levels.
However, CTS exhibited little effect on CTGF activation and on COX-2 suppression.
Finally, CTS treatment significantly mitigated the radiation-induced activation of CCL3 and its receptor CCR1.
In summary, CTS treatment could attenuate RILI, especially pulmonary fibrosis, in rats.
The regulation on production and release of inflammatory or fibrotic factors IL-6, IL-10, TGF-β1, NOX-4, and MMP-1, especially MMP-1 and inhibition on CCL3/CCR1 activation, may partly attribute to its attenuating RILI effect.
American Psychological Association (APA)
Jiang, Yifang& You, Fengming& Zhu, Jie& Zheng, Chuan& Yan, Ran& Zeng, Jinhao. 2019. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148774
Modern Language Association (MLA)
Jiang, Yifang…[et al.]. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1148774
American Medical Association (AMA)
Jiang, Yifang& You, Fengming& Zhu, Jie& Zheng, Chuan& Yan, Ran& Zeng, Jinhao. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148774