Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence
المؤلفون المشاركون
Wei, Jiahui
Zhao, Binxin
Zhang, Chengling
Shen, Bingbing
Zhang, Ying
Li, Changxi
Chen, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine.
Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms.
To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction.
Molecular docking and validation in vivo were investigated by the proapoptotic mechanisms of JFS.
In this study, 99 common targets were related to 108 diseases.
484 biological processes, 44 cell components, 59 molecular functions, and 37 pathways were significantly identified in GO enrichment and pathway analysis.
In molecular docking, ligustrazine showed binding activity with Bcl-2, Bax, caspase-9, caspase-3, and PARP.
In vivo, JFS elevated the shrink rate of ectopic endometrium, by suppressing E2 and PROG.
An in-depth study showed that apoptosis was activated through diminishing Bcl-2, rising Bax and Bad, and expressing more caspase-3 and caspase-9 using JFS.
JFS promoted the protein level of cleaved-PARP.
In brief, JFS might be applied for various diseases through multiple targets and pathways, especially endometriosis by Bcl-2 pathway.
These findings reveal the potential application for further evaluation and uncover the proapoptotic mechanism of JFS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Binxin& Zhang, Chengling& Shen, Bingbing& Zhang, Ying& Li, Changxi& Chen, Yi…[et al.]. 2019. Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Binxin…[et al.]. Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1148904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Binxin& Zhang, Chengling& Shen, Bingbing& Zhang, Ying& Li, Changxi& Chen, Yi…[et al.]. Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر