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Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence
Joint Authors
Wei, Jiahui
Zhao, Binxin
Zhang, Chengling
Shen, Bingbing
Zhang, Ying
Li, Changxi
Chen, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine.
Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms.
To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction.
Molecular docking and validation in vivo were investigated by the proapoptotic mechanisms of JFS.
In this study, 99 common targets were related to 108 diseases.
484 biological processes, 44 cell components, 59 molecular functions, and 37 pathways were significantly identified in GO enrichment and pathway analysis.
In molecular docking, ligustrazine showed binding activity with Bcl-2, Bax, caspase-9, caspase-3, and PARP.
In vivo, JFS elevated the shrink rate of ectopic endometrium, by suppressing E2 and PROG.
An in-depth study showed that apoptosis was activated through diminishing Bcl-2, rising Bax and Bad, and expressing more caspase-3 and caspase-9 using JFS.
JFS promoted the protein level of cleaved-PARP.
In brief, JFS might be applied for various diseases through multiple targets and pathways, especially endometriosis by Bcl-2 pathway.
These findings reveal the potential application for further evaluation and uncover the proapoptotic mechanism of JFS.
American Psychological Association (APA)
Zhao, Binxin& Zhang, Chengling& Shen, Bingbing& Zhang, Ying& Li, Changxi& Chen, Yi…[et al.]. 2019. Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148904
Modern Language Association (MLA)
Zhao, Binxin…[et al.]. Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1148904
American Medical Association (AMA)
Zhao, Binxin& Zhang, Chengling& Shen, Bingbing& Zhang, Ying& Li, Changxi& Chen, Yi…[et al.]. Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148904