Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model
المؤلفون المشاركون
Liao, Chung-Chih
Li, Jung-Miao
Hsieh, Ching-Liang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The study aimed to investigate effect of auricular electrical stimulation (ES) on migraine.
Migraine was induced in rats by intraperitoneal administration of nitroglycerin (NTG, 10 mg/kg) three times.
Auricular ES pretreatment was performed for five consecutive days.
Migraine behaviors were observed by a video recording.
Auricular ES pretreatment could reverse the decrease of the total time spent on exploratory (2619.0 ± 113.0 s vs 1581.7 ± 217.6 s, p=0.0029) and locomotor behaviors (271.3 ± 21.4 s vs 114.3 ± 19.7 s, p=0.0135) and also could reverse the increase of the total time spent on resting (19.0 ± 10.6 s vs 154.3 ± 46.5 s, p=0.0398) and grooming (369.9 ± 66.8 s vs 1302.0 ± 244.5 s, p=0.0324) behaviors.
Auricular ES pretreatment could increase the frequency of rearing behaviors (38.0 ± 1.8 vs 7.7 ± 3.5, p<0.0001) and total distance traveled (1372.0 ± 157.9 cm vs 285.3 ± 85.6 cm, p<0.0001) and also could increase the percentage of inner zone time (6.0 ± 1.6% vs 0.4 ± 0.2%, p=0.0472).
The CGRP, COX-2, TRPV1, and TRPA1 immunoreactive cells in the trigeminal ganglion increased in the NTG group compared with the control group (all p<0.0001); this increase could, however, be reduced by auricular ES pretreatment (27.8 ± 2.6 vs 63.0 ± 4.2, p<0.0001; 21.7 ± 1.2 vs 61.8 ± 4.0, p<0.0001; 24.3 ± 1.0 vs 36.5 ± 1.7, p=0.0003; and 20.7 ± 1.9 vs 90.8 ± 6.5, p<0.0001, respectively).
Therefore, we suggest that auricular ES pretreatment is beneficial for the treatment of migraine and this effect is partly related to CGRP/COX-2/TRPV1/TRPA1 signaling pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liao, Chung-Chih& Li, Jung-Miao& Hsieh, Ching-Liang. 2019. Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148932
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liao, Chung-Chih…[et al.]. Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1148932
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liao, Chung-Chih& Li, Jung-Miao& Hsieh, Ching-Liang. Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148932
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148932
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر