Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model
Joint Authors
Liao, Chung-Chih
Li, Jung-Miao
Hsieh, Ching-Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The study aimed to investigate effect of auricular electrical stimulation (ES) on migraine.
Migraine was induced in rats by intraperitoneal administration of nitroglycerin (NTG, 10 mg/kg) three times.
Auricular ES pretreatment was performed for five consecutive days.
Migraine behaviors were observed by a video recording.
Auricular ES pretreatment could reverse the decrease of the total time spent on exploratory (2619.0 ± 113.0 s vs 1581.7 ± 217.6 s, p=0.0029) and locomotor behaviors (271.3 ± 21.4 s vs 114.3 ± 19.7 s, p=0.0135) and also could reverse the increase of the total time spent on resting (19.0 ± 10.6 s vs 154.3 ± 46.5 s, p=0.0398) and grooming (369.9 ± 66.8 s vs 1302.0 ± 244.5 s, p=0.0324) behaviors.
Auricular ES pretreatment could increase the frequency of rearing behaviors (38.0 ± 1.8 vs 7.7 ± 3.5, p<0.0001) and total distance traveled (1372.0 ± 157.9 cm vs 285.3 ± 85.6 cm, p<0.0001) and also could increase the percentage of inner zone time (6.0 ± 1.6% vs 0.4 ± 0.2%, p=0.0472).
The CGRP, COX-2, TRPV1, and TRPA1 immunoreactive cells in the trigeminal ganglion increased in the NTG group compared with the control group (all p<0.0001); this increase could, however, be reduced by auricular ES pretreatment (27.8 ± 2.6 vs 63.0 ± 4.2, p<0.0001; 21.7 ± 1.2 vs 61.8 ± 4.0, p<0.0001; 24.3 ± 1.0 vs 36.5 ± 1.7, p=0.0003; and 20.7 ± 1.9 vs 90.8 ± 6.5, p<0.0001, respectively).
Therefore, we suggest that auricular ES pretreatment is beneficial for the treatment of migraine and this effect is partly related to CGRP/COX-2/TRPV1/TRPA1 signaling pathways.
American Psychological Association (APA)
Liao, Chung-Chih& Li, Jung-Miao& Hsieh, Ching-Liang. 2019. Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148932
Modern Language Association (MLA)
Liao, Chung-Chih…[et al.]. Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1148932
American Medical Association (AMA)
Liao, Chung-Chih& Li, Jung-Miao& Hsieh, Ching-Liang. Auricular Electrical Stimulation Alleviates Headache through CGRPCOX-2TRPV1TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148932