Investigation of the Optimum Preparation of Peach Gum Polysaccharides and the In Vivo and In Vitro Therapeutic Effects on Acute Pyelonephritis
المؤلفون المشاركون
Yang, Guangzhong
Zhang, Feifei
Bai, Jie
Zheng, Yao
Liang, Shuai
Lei, Lei
Deng, Xin
Li, Weijun
Liu, Peng
Ren, Yongshen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-12
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Background.
Acute pyelonephritis (APN), known as stranguria in traditional Chinese medicine, is commonly treated with antibiotics.
However, the rise in antibiotic resistance and the high rates of recurrence of APN make its treatment complicated, thus the development of alternative therapies is critical.
Peach gum has long been recognized by traditional Chinese medicine as a food with medicinal value of relieving stranguria, but whether and how its primary constituent peach gum polysaccharides (PGPs) contribute to the diuretic function is still not clear.
Purpose.
The aim of this study was to investigate the optimum extraction process of PGPs and to evaluate its therapeutic effect on APN rats and to discover the underlying mechanism.
Methods.
In this study, surface design optimization was adopted to optimize the preparation of PGPs and HPLC and FT-IR spectra were used to evaluate the quality of PGPs; APN model rat was established by the Escherichia coli urinary tract infection method; the therapeutic effect and mechanism of PGPs on APN were determined by the visceral index, biochemical indicators, pathological section of the APN rat, and diuretic activity on mice and antibacterial activity in vitro.
Results.
Compared with an untreated APN group, the results showed that treatment with PGPs increased the APN-induced attenuation of secretory immunoglobulin A (sIgA) and creatinine clearance and decreased the APN-induced enhancement of the number of white blood cell (WBC), neutrophil counts (NC), bacteria load of the kidneys, kidney index, serum creatinine, urine volume, blood urea nitrogen (BUN), and interleukin-2 (IL-2) levels.
The mechanism underlying these effects was further elucidated through in vitro experiments of the antibacterial and antiadhesion effects of PGPs.
Conclusion.
Due to the good therapeutic effects and advantages of PGPs, it could be considered as an alternative medicine to treat APN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Feifei& Bai, Jie& Zheng, Yao& Liang, Shuai& Lei, Lei& Deng, Xin…[et al.]. 2019. Investigation of the Optimum Preparation of Peach Gum Polysaccharides and the In Vivo and In Vitro Therapeutic Effects on Acute Pyelonephritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1149101
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Feifei…[et al.]. Investigation of the Optimum Preparation of Peach Gum Polysaccharides and the In Vivo and In Vitro Therapeutic Effects on Acute Pyelonephritis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1149101
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Feifei& Bai, Jie& Zheng, Yao& Liang, Shuai& Lei, Lei& Deng, Xin…[et al.]. Investigation of the Optimum Preparation of Peach Gum Polysaccharides and the In Vivo and In Vitro Therapeutic Effects on Acute Pyelonephritis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1149101
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149101
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر