Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling
المؤلفون المشاركون
Chen, Jianping
Wang, Fochang
Huang, Shiying
Liu, Xiaoyan
Li, Zhonggui
Qi, Airong
Liu, Xinhui
Yi, Tiegang
Li, Shunmin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Jian-Pi-Yi-Shen (JPYS) is one of the herbal medicines for treatment of anemic patients with chronic kidney disease (CKD).
However, less of scientific evidence to support JPYS involved in treating anemia has been revealed.
Here, an animal study was performed to investigate its hematopoietic activities and the underlying mechanism.
The 5/6 nephrectomized inductions of CKD anemic rats were randomly divided into two groups: CKD group and JPYS group.
Sham-operated rats served as sham group.
JPYS (1.36 g/kg/d) was administered orally to CKD rats daily for six consecutive weeks.
Results showed that JPYS treatment notably improved renal function and pathological injury in CKD rats.
JPYS also restored the hematological parameters, including red blood cells, hemoglobin, and hematocrit.
In parallel, the reduction level of EPO was reversed by JPYS.
Furthermore, JPYS induced the accumulation of hypoxia inducible factor (HIF)-α protein expression.
Collectively, these results provide convincing evidence for JPYS decoction in ameliorating CKD-associated anemia, and its mechanism might be related to regulate EPO production via HIF signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Jianping& Wang, Fochang& Huang, Shiying& Liu, Xiaoyan& Li, Zhonggui& Qi, Airong…[et al.]. 2019. Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1149126
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Jianping…[et al.]. Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1149126
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Jianping& Wang, Fochang& Huang, Shiying& Liu, Xiaoyan& Li, Zhonggui& Qi, Airong…[et al.]. Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1149126
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149126
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر