Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling
Joint Authors
Chen, Jianping
Wang, Fochang
Huang, Shiying
Liu, Xiaoyan
Li, Zhonggui
Qi, Airong
Liu, Xinhui
Yi, Tiegang
Li, Shunmin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Jian-Pi-Yi-Shen (JPYS) is one of the herbal medicines for treatment of anemic patients with chronic kidney disease (CKD).
However, less of scientific evidence to support JPYS involved in treating anemia has been revealed.
Here, an animal study was performed to investigate its hematopoietic activities and the underlying mechanism.
The 5/6 nephrectomized inductions of CKD anemic rats were randomly divided into two groups: CKD group and JPYS group.
Sham-operated rats served as sham group.
JPYS (1.36 g/kg/d) was administered orally to CKD rats daily for six consecutive weeks.
Results showed that JPYS treatment notably improved renal function and pathological injury in CKD rats.
JPYS also restored the hematological parameters, including red blood cells, hemoglobin, and hematocrit.
In parallel, the reduction level of EPO was reversed by JPYS.
Furthermore, JPYS induced the accumulation of hypoxia inducible factor (HIF)-α protein expression.
Collectively, these results provide convincing evidence for JPYS decoction in ameliorating CKD-associated anemia, and its mechanism might be related to regulate EPO production via HIF signaling pathway.
American Psychological Association (APA)
Chen, Jianping& Wang, Fochang& Huang, Shiying& Liu, Xiaoyan& Li, Zhonggui& Qi, Airong…[et al.]. 2019. Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1149126
Modern Language Association (MLA)
Chen, Jianping…[et al.]. Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1149126
American Medical Association (AMA)
Chen, Jianping& Wang, Fochang& Huang, Shiying& Liu, Xiaoyan& Li, Zhonggui& Qi, Airong…[et al.]. Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 56 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1149126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149126