Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model

المؤلفون المشاركون

Komasawa, Nobuyasu
Nakao, Kenta
Fujiwara, Atsushi
Jin, Denan
Kitano, Manabu
Matsunami, Sayuri
Takai, Shinji
Ito, Seiji
Minami, Toshiaki

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-05-26

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

Bone cancer pain control is difficult because it includes various characteristics of pain such as nociceptic and neuropathic pain.

In this study, we investigated the effect of yokukansan (YKS), one of the traditional Japanese herbal medicines, on cancer pain in mouse bone metastasis model.

Oral administration of YKS significantly alleviated pain behavior measured by quantitative body weight bearing.

Furthermore, the pain behavior was also significantly alleviated by intrathecal and intraperitoneal administration of matrix metalloproteinase- (MMP-) 9 inhibitor, but not of MMP-2 inhibitor.

MMP-9 expression was significantly elevated in the bone tissue on day 3 after carcinoma cell injection and in the ipsilateral spinal cord on day 7, which was suppressed by YKS administration.

Taken together, these results suggest that YKS alleviates cancer pain via suppressing MMP-9 expression in bone metastasis model in mice.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nakao, Kenta& Fujiwara, Atsushi& Komasawa, Nobuyasu& Jin, Denan& Kitano, Manabu& Matsunami, Sayuri…[et al.]. 2019. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149181

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nakao, Kenta…[et al.]. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1149181

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nakao, Kenta& Fujiwara, Atsushi& Komasawa, Nobuyasu& Jin, Denan& Kitano, Manabu& Matsunami, Sayuri…[et al.]. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149181

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1149181