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Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model
Joint Authors
Komasawa, Nobuyasu
Nakao, Kenta
Fujiwara, Atsushi
Jin, Denan
Kitano, Manabu
Matsunami, Sayuri
Takai, Shinji
Ito, Seiji
Minami, Toshiaki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bone cancer pain control is difficult because it includes various characteristics of pain such as nociceptic and neuropathic pain.
In this study, we investigated the effect of yokukansan (YKS), one of the traditional Japanese herbal medicines, on cancer pain in mouse bone metastasis model.
Oral administration of YKS significantly alleviated pain behavior measured by quantitative body weight bearing.
Furthermore, the pain behavior was also significantly alleviated by intrathecal and intraperitoneal administration of matrix metalloproteinase- (MMP-) 9 inhibitor, but not of MMP-2 inhibitor.
MMP-9 expression was significantly elevated in the bone tissue on day 3 after carcinoma cell injection and in the ipsilateral spinal cord on day 7, which was suppressed by YKS administration.
Taken together, these results suggest that YKS alleviates cancer pain via suppressing MMP-9 expression in bone metastasis model in mice.
American Psychological Association (APA)
Nakao, Kenta& Fujiwara, Atsushi& Komasawa, Nobuyasu& Jin, Denan& Kitano, Manabu& Matsunami, Sayuri…[et al.]. 2019. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149181
Modern Language Association (MLA)
Nakao, Kenta…[et al.]. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1149181
American Medical Association (AMA)
Nakao, Kenta& Fujiwara, Atsushi& Komasawa, Nobuyasu& Jin, Denan& Kitano, Manabu& Matsunami, Sayuri…[et al.]. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149181